Vol. 7, Issue 2, Part C (2025)

Background: Reliance on a narrow set of pesticide modes of action has accelerated resistance in key agricultural pests, with parallel concerns about human exposure and food-residue safety. Objectives: To quantify resistance magnitudes across major pest-chemistry combinations, characterize residue exceedance in food and soil, examine acute health symptoms across exposure tiers, and evaluate whether a targeted educational program improves knowledge and adoption of integrated pest management (IPM). Methods: Replicated bioassays estimated LC₅₀-based resistance ratios (RR) for Helicoverpa armigera, Plutella xylostella, and Nilaparvata lugens against pyrethroid, organophosphate, and neonicotinoid classes, with bootstrap confidence intervals. Residue monitoring (GC-MS) assessed concentrations and maximum residue limit (MRL) exceedance in rice, okra, tomato, and topsoil. A cross-sectional farmer survey recorded acute symptoms by exposure tier and generated odds ratios (OR) for high vs low exposure. A pre-post educational intervention measured knowledge scores (0-20 scale), permutation-test significance, effect size, and 90-day IPM adoption. Results: RRs indicated entrenched resistance, with H. armigera showing the highest values to pyrethroids (~7-8) and N. lugens elevated to neonicotinoids (~5), while P. xylostella exhibited broad cross-resistance. Residue exceedance occurred in ~20-35% of samples depending on commodity. Acute symptom prevalence increased monotonically from low to high exposure, with significantly higher odds in the high tier. Education yielded moderate-to-large knowledge gains (≈4-5 points) and raised IPM adoption from ~28% to ~61% within 90 days. Conclusions: Resistance is widespread and functionally consequential; residue exceedances and an exposure-symptom gradient underscore public-health relevance. A blended strategy—IRAC-aligned rotation, diversified controls, residue stewardship, and structured education—offers a feasible pathway to safeguard yields, workers, and ecosystems.